Translational Mini-Review Series on B cell subsets in disease. Reconstitution after haematopoietic stem cell transplantation - revelation of B cell developmental pathways and lineage phenotypes

被引：49

作者：

Bemark, M. ^{[1
,3
]}

Holmqvist, J. ^{[1
,3
]}

Abrahamsson, J. ^{[2
]}

Mellgren, K. ^{[2
]}

机构：

[1] Gothenburg Univ, Dept Microbiol & Immunol, S-40530 Gothenburg, Sweden

[2] Gothenburg Univ, Inst Clin Sci, S-40530 Gothenburg, Sweden

[3] Sahlgrens Univ Hosp, Dept Clin Immunol & Transfus Med, Gothenburg, Sweden

来源：

CLINICAL AND EXPERIMENTAL IMMUNOLOGY | 2012年 / 167卷 / 01期

基金：

瑞典研究理事会;

关键词：

B cell; haematopoietic stem cell transplantation; lymphocyte development; BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; PREVENTING INFECTIOUS COMPLICATIONS; ACUTE LYMPHOBLASTIC-LEUKEMIA; NON-HODGKINS LYMPHOMA; EPSTEIN-BARR-VIRUS; PERIPHERAL-BLOOD; T-CELL; IMMUNE RECONSTITUTION; IGM MEMORY;

D O I：

10.1111/j.1365-2249.2011.04469.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Haematopoietic stem cell transplantation (HSCT) is an immunological treatment that has been used for more than 40 years to cure a variety of diseases. The procedure is associated with serious side effects, due to the severe impairment of the immune system induced by the treatment. After a conditioning regimen with high-dose chemotherapy, sometimes in combination with total body irradiation, haematopoietic stem cells are transferred from a donor, allowing a donor-derived blood system to form. Here, we discuss the current knowledge of humoral problems and B cell development after HSCT, and relate these to the current understanding of human peripheral B cell development. We describe how these studies have aided the identification of subsets of transitional B cells and also a robust memory B cell phenotype.

引用

页码：15 / 25

页数：11

共 108 条

[11] B lymphocyte reconstitution after hernatopoietic stem cell transplantation:: functional immaturity and slow recovery of memory CD27+ B cells [J].