The T-cell repertoire available for recognition of self-antigens

被引：24

作者：

Kreuwel, HTC ^{[1
]}

Sherman, LA ^{[1
]}

机构：

[1] Scripps Res Inst, Dept Immunol, La Jolla, CA 92037 USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2001年 / 13卷 / 06期

关键词：

D O I：

10.1016/S0952-7915(01)00272-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Autoimmunity can be viewed as the price we pay in order to have a highly diverse TCR repertoire. This is not to say that every effort isn't made by the immune system to prevent autoimmune disease. During thymic development, and later in the periphery, the TCR repertoire is continuously purged of cells that are activated by self-antigens. Other lymphocytes are recruited to join a legion of T regulatory cells that assist in preventing 'friendly fire', Recent studies continue to reveal the importance of the composition of the T cell repertoire in predisposing an individual to autoimmune disease.

引用

页码：639 / 643

页数：5

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