CENP-B specific anti-centromere autoantibodies heralding small-cell lung cancer - A case study and review of the literature

被引：13

作者：

Briasoulis, Evangelos ^{[1
,2
]}

Kamposioras, Konstantinos ^{[2
]}

Tzovaras, Vasilis

Pafitanis, George ^{[1
]}

Kostoula, Angeliki ^{[3
]}

Mavridis, Anestis ^{[1
,3
]}

Pavlidis, Nicholas ^{[1
,2
]}

机构：

[1] Univ Ioannina, Dept Med Oncol, Ioannina 45500, Greece

[2] Ioannina Univ Hosp, Dept Med Oncol, Ioannina, Greece

[3] Ioannina Univ Hosp, Lab Immunol & Microbiol, Ioannina, Greece

来源：

LUNG CANCER | 2008年 / 60卷 / 02期

关键词：

carcinoma; small-cell lung; autoantibodies; centromere-protein-B; tumor-markers;

D O I：

10.1016/j.lungcan.2007.09.014

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report on a small-cell lung cancer case that was heralded by the presence of CENP-B specific anti-centromere autoantibodies (ACA) detected well before the diagnosis of cancer. The patient received chemotherapy plus radiotherapy, which resulted in complete remission of the tumor. Serum ACA levels were zeroed at the time of radiological documentation of tumor response and remained undetected at serial follow-up assessments until they rose again along with documentation of tumor recurrence which occurred 12 months later. We review in brief published research and discuss anti-centromere autoantibodies as potential biomarkers in small-cell lung cancer, a highly proliferative tumor which lacks sensitive serum markers. (C) 2007 Elsevier Ireland Ltd. All rights reserved.

引用

页码：302 / 306

页数：5

共 29 条

[1] Cancer and autoimmunity: autoimmune and rheumatic features in patients with malignancies [J].

Abu-Shakra, M ;

Buskila, D ;

Ehrenfeld, M ;

Conrad, K ;

Shoenfeld, Y .

ANNALS OF THE RHEUMATIC DISEASES, 2001, 60 (05) :433-440

[2] CENP-A, -B, and -C chromatin complex that contains the I-type α-satellite array constitutes the prekinetochore in HeLa cells [J].

Ando, S ;

Yang, H ;

Nozaki, N ;

Okazaki, T ;

Yoda, K .

MOLECULAR AND CELLULAR BIOLOGY, 2002, 22 (07) :2229-2241

[3]

Atalay C, 2005, NEOPLASMA, V52, P32

[4] Prevalence of anticentromere F protein autoantibodies in 347 patients with non-Hodgkin's lymphoma [J].

Bencimon, C ;

Salles, G ;

Moreira, A ;

Guyomard, S ;

Coiffier, B ;

Bienvenu, J ;

Fabien, N .

AUTOIMMUNITY: CONCEPTS AND DIAGNOSIS AT THE CUTTING EDGE, 2005, 1050 :319-326

[5] Autoantibodies to mitotic apparatus: Association with other autoantibodies and their clinical significance [J].

Bonaci-Nikolic, Branka ;

Andrejevic, Sladjana ;

Bukilica, Mirjana ;

Urosevic, Ivana ;

Nikolic, Milos .

JOURNAL OF CLINICAL IMMUNOLOGY, 2006, 26 (05) :438-446

[6] AUTOIMMUNITY TO THE CELL CYCLE-DEPENDENT CENTROMERE PROTEIN P330(D)/CENP-F IN DISORDERS ASSOCIATED WITH CELL-PROLIFERATION [J].

CASIANO, CA ;

HUMBEL, RL ;

PEEBLES, C ;

COVINI, G ;

TAN, EM .

JOURNAL OF AUTOIMMUNITY, 1995, 8 (04) :575-586

[7] Autoantibodies in breast cancer: their use as an aid to early diagnosis [J].

Chapman, C. ;

Murray, A. ;

Chakrabarti, J. ;

Thorpe, A. ;

Woolston, C. ;

Sahin, U. ;

Barnes, A. ;

Robertson, J. .

ANNALS OF ONCOLOGY, 2007, 18 (05) :868-873

[8]

Erlanson M, 1999, MODERN PATHOL, V12, P69

[9]

FERNANDEZ MF, 2005, CANC DETECT PREV, V29, P59

[10]

Fernández-Madrid F, 1999, CLIN CANCER RES, V5, P1393

← 1 2 3 →