WSX-1 is required for the initiation of Th1 responses and resistance to L-major infection

被引：359

作者：

Yoshida, H

Hamano, S

Senaldi, G

Covey, T

Faggioni, R

Mu, S

Xia, M

Wakeham, AC

Nishina, H

Potter, J

Saris, CJM

Mak, TW ^{[1
]}

机构：

[1] Univ Toronto, Amgen Inst, Toronto, ON M5G 2C1, Canada

[2] Univ Toronto, Ontario Canc Inst, Toronto, ON M5G 2C1, Canada

[3] Univ Toronto, Dept Med Biophys, Toronto, ON M5G 2C1, Canada

[4] Univ Toronto, Dept Immunol, Toronto, ON M5G 2C1, Canada

[5] Kyushu Univ, Fac Med Sci, Dept Parasitol, Higashi Ku, Fukuoka 8128582, Japan

[6] Kyushu Univ, Med Inst Bioregulat, Dept Immunol, Higashi Ku, Fukuoka 8128582, Japan

[7] Amgen Inc, Dept Pharmacol Pathol, Thousand Oaks, CA 91320 USA

[8] Amgen Inc, Dept Inflammat Res, Thousand Oaks, CA 91320 USA

来源：

IMMUNITY | 2001年 / 15卷 / 04期

关键词：

D O I：

10.1016/S1074-7613(01)00206-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

WSX-1 is a class I cytokine receptor with homology to the IL-12 receptors. The physiological role of WSX-1, which is expressed mainly in T cells, was investigated in gene-targeted WSX-1-deficient mice. IFN-gamma production was reduced in isolated WSX-1(-/-) T cells subjected to primary stimulation in vitro to induce Th1 differentiation but was normal in fully differentiated and activated WSX-1(-/-) Th1 cells that had received secondary stimulation. WSX-1(-/-) mice were remarkably susceptible to Leishmania major infection, showing impaired IFN-gamma production early in the infection. However, IFN-gamma production during the later phases of the infection was not impaired in the knockout. WSX-1(-/-) mice also showed poorly differentiated granulomas with dispersed accumulations of mononuclear cells when infected with bacillus Calmette-Guerin (BCG). Thus,WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance.

引用

页码：569 / 578

页数：10

共 34 条

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