Modulation of Rho GTPases and the actin cytoskeleton by Yersinia outer proteins (Yops)

被引：35

作者：

Aepfelbacher, M ^{[1
]}

Heesemann, J ^{[1
]}

机构：

[1] Max von Pettenkofer Inst Hyg & Med Mikrobiol, D-80336 Munich, Germany

来源：

INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY | 2001年 / 291卷 / 04期

关键词：

Yersinia; actin cytoskeleton; Rho GTPases; phagocytosis; signalling;

D O I：

10.1078/1438-4221-00130

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Pathogenic species of the genus Yersinia employ a type III secretion apparatus to inject up to six effector proteins (Yersinia outer proteins; Yops) into host cells. Thereby yersiniae disarm the immune cell system of the host to proliferate extracellularly. At least four of the Yop effectors (YopE, YpkA/YopO, YopT and YopH) are involved in the rearrangement of the actin cytoskeleton: YopE, YopT and YpkA/YopO modulate the activity of actin-regulating Rho GTP-binding proteins, whereas YopH dephosphorylates phospho-tyrosine residues in focal adhesion proteins. In this review we will focus on recent evidence implicating Rho GTPases and the actin cytoskeleton as major targets of Yersinia Yops.

引用

页码：269 / 276

页数：8

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