Immunometabolism of infections

被引：55

作者：

Ayres, Janelle S. ^{[1
,2
]}

机构：

[1] Salk Inst Biol Studies, Mol & Syst Physiol Lab, Gene Express Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Nomis Ctr Immunobiol & Microbial Pathogenesis, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2020年 / 20卷 / 02期

关键词：

TOLERANCE;

D O I：

10.1038/s41577-019-0266-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Physiological studies of infection biology revealed decades ago that there is an intimate relationship between the immune system and the host metabolic system. These interactions begin soon after pathogen detection and continue to evolve over the course of the infection. A relatively recent resurgence in interest in the interface between immunity and metabolism gave rise to the field of 'immunometabolism', a term that was coined in 2011. Immunometabolic studies have mainly focused on the cellular level and on non-infectious diseases such as metabolic syndrome, with surprisingly few studies involving infections. In 2019, several studies started to elucidate the relationship between metabolism and the immune response to infectious diseases on both the cellular and the organismal levels. Moreover, 2019 saw the re-emergence of invertebrate animal models to study immunometabolism and infection.

引用

页码：79 / 80

页数：2

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