Regulation of skeletal myogenesis by Notch

被引：92

作者：

Buas, Matthew F. ^{[1
]}

Kadesch, Tom ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Dept Genet, Philadelphia, PA 19104 USA

来源：

EXPERIMENTAL CELL RESEARCH | 2010年 / 316卷 / 18期

关键词：

Notch; Muscle; ASYMMETRIC CELL-DIVISION; SATELLITE STEM-CELLS; LOOP-HELIX FACTORS; PROGENITOR CELLS; SIGNALING PATHWAY; MUSCLE; DIFFERENTIATION; TRANSCRIPTION; ACTIVATION; ENHANCER;

D O I：

10.1016/j.yexcr.2010.05.002

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Notch signaling has emerged as a key player in skeletal muscle development and regeneration. Simply stated, Notch signaling inhibits differentiation. Accordingly, fine-tuning the pathway is essential for proper muscle homeostasis. This review will address various aspects of Notch signaling, including our current views of the core pathway, its effects in muscle, its interactions with other signaling pathways, and its relationship with ageing. (C) 2010 Elsevier Inc. All rights reserved.

引用

页码：3028 / 3033

页数：6

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