Assessment of drug-induced QT prolongation: To bin or not to bin?

被引:13
作者
Malik, M [1 ]
机构
[1] St George Hosp, Sch Med, Dept Cardiac & Vasc Sci, London SW17 0RE, England
关键词
D O I
10.1016/j.clpt.2004.11.004
中图分类号
R9 [药学];
学科分类号
1007 [药学];
摘要
引用
收藏
页码:241 / 246
页数:6
相关论文
共 10 条
[1]
QT-RR relationship in healthy subjects exhibits substantial intersubject variability and high intrasubject stability [J].
Batchvarov, VN ;
Ghuran, A ;
Smetana, P ;
Hnatkova, K ;
Harries, M ;
Dilaveris, P ;
Camm, AJ ;
Malik, M .
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY, 2002, 282 (06) :H2356-H2363
[2]
Clinical assessment of drug-induced QT prolongation in association with heart rate changes [J].
Extramiana, F ;
Maison-Blanche, P ;
Cabanis, M ;
Ortemann-Renon, C ;
Beaufils, P ;
Leenhardt, A .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2005, 77 (04) :247-258
[3]
Drug-induced Torsades de Pointes and implications for drug development [J].
Fenichel, RR ;
Malik, M ;
Antzelevitch, C ;
Sanguinetti, M ;
Roden, DM ;
Priori, SG ;
Ruskin, JN ;
Lipicky, RJ ;
Cantilena, LR .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2004, 15 (04) :475-495
[4]
*INT C HARM, CLIN EV QT QTC INT P
[5]
HYSTERESIS OF THE VENTRICULAR PACED QT INTERVAL IN RESPONSE TO ABRUPT CHANGES IN PACING RATE [J].
LAU, CP ;
FREEDMAN, AR ;
FLEMING, S ;
MALIK, M ;
CAMM, AJ ;
WARD, DE .
CARDIOVASCULAR RESEARCH, 1988, 22 (01) :67-72
[7]
Differences between study-specific and subject-specific heart rate corrections of the QT interval in investigations of drug induced QTc prolongation [J].
Malik, M ;
Hnatkova, K ;
Batchvarov, V .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2004, 27 (06) :791-800
[8]
The imprecision in heart rate correction may lead to artificial observations of drug induced QT interval changes [J].
Malik, M .
PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY, 2002, 25 (02) :209-216
[9]
Characterization of QT interval adaptation to RR interval changes and its use as a risk-stratifier of arrhythmic mortality in amiodarone-treated survivors of acute myocardial infarction [J].
Pueyo, E ;
Smetana, P ;
Caminal, P ;
de Luna, AB ;
Malik, M ;
Laguna, P .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2004, 51 (09) :1511-1520
[10]
Linearly scaled, rate-invariant normal limits for QT interval: Eight decades of incorrect application of power functions [J].
Rautaharju, PM ;
Zhang, ZM .
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY, 2002, 13 (12) :1211-1218