The role of tissue microarrays in prostate cancer biomarker discovery

被引：11

作者：

Datta, Milton W.

True, Lawrence D.

Nelson, Peter S.

Amin, Mahul B.

机构：

[1] Univ Minnesota, Hosp Pathol Assoc, Minneapolis, MN USA

[2] Univ Minnesota, Dept Pathol, Minneapolis, MN 55455 USA

[3] Univ Washington, Dept Pathol, Seattle, WA 98195 USA

[4] Fred Hutchinson Canc Res Ctr, Dept Hematol Oncol, Seattle, WA 98104 USA

[5] Univ Calif Los Angeles, Cedars Sinai Med Ctr, Dept Pathol, Los Angeles, CA 90048 USA

来源：

ADVANCES IN ANATOMIC PATHOLOGY | 2007年 / 14卷 / 06期

关键词：

D O I：

10.1097/PAP.0b013e318155709a

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Tissue microarrays (TMAs) offer the potential to rapidly translate genomics and basic science research findings to practical clinical application. This is particularly true in the field of cancer biomarker research, where TMAs can be used for candidate biomarker validation and association with patient clinical, pathologic, and outcomes parameters. In this review, we examine the effect of TMA use on prostate cancer biomarker research, focusing on the types of TMAs that have been used, and the biomarkers that have been examined. The results demonstrate that TMAs have been very effective in screening candidate biomarkers for subsequent, extended evaluation in large patient populations. In addition, the use of TMAs in multiple biomarker series allows for the statistical analysis of sets of biomarkers as diagnostic or prognostic tests. The processes used here can be applied to any tumor type to improve patient diagnosis, prognosis, and treatment response prediction.

引用

页码：408 / 418

页数：11

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