Endotoxinemia in the portal and the systemic circulation in obstructive jaundice

被引：50

作者：

Papakostas, C

Bezirtzoglou, E ^{[1
]}

Pitiakoudis, M

Polychronidis, A

Simopoulos, C

机构：

[1] Univ Ioannina, Sch Med, Dept Microbiol, GR-45110 Ioannina, Greece

[2] Democritus Univ Thrace, Sch Med, Dept Expt Surg, Alexandroupolis, Greece

来源：

CLINICAL AND EXPERIMENTAL MEDICINE | 2003年 / 3卷 / 02期

关键词：

obstructive jaundice; endotoxinemia; portal circulation; systemic circulation;

D O I：

10.1007/s10238-003-0015-y

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 [基础医学];

摘要：

Endotoxinemia in patients with obstructive jaundice is linked to acute renal failure and sepsis and remains a major cause of complications during postoperative treatment. The current study examines the mechanisms of endotoxinemia in the portal and the systemic circulation in obstructive jaundice. As an experimental model of the disease we used rabbits subjected to sham operation. Serum total bilirubin aminotransferases and endotoxin concentrations were determined at 2, 5, 8, and 13 days after operation. Endotoxin concentrations were estimated by the limulus lysate endotoxin test. A high frequency of portal or systemic endotoxinemia is observed in obstructive jaundice, but no difference between endotoxinemia levels in the portal and systemic circulation was observed.

引用

页码：124 / 128

页数：5

共 17 条

[1]

ENDOTOXIN, BILE-SALTS AND RENAL-FUNCTION IN OBSTRUCTIVE-JAUNDICE [J].