Applications of N-BOC-diamines for the solution phase synthesis of ketopiperazine libraries utilizing a Ugi/De-BOC/Cyclization (UDC) strategy

被引：61

作者：

Hulme, C ^{[1
]}

Peng, J ^{[1
]}

Louridas, B ^{[1
]}

Menard, P ^{[1
]}

Krolikowski, P ^{[1
]}

Kumar, NV ^{[1
]}

机构：

[1] Rhone Poulenc Rorer Cent Res, New Leads Discovery, Collegeville, PA 19426 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 44期

关键词：

D O I：

10.1016/S0040-4039(98)01770-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This communication reveals a novel application of the 'so-called' convertible isonitrile for the solution phase generation of ketopiperazine libraries. Use of mono N-BOC diamines in the Ugi multicomponent reaction (MCR), followed by BOC removal and base treatment (a '3 step, 1-pot procedure') affords ketopiperazines in good yield. The generality of this procedure was further explored revealing novel routes to dihydroquinoxalinones and 1,4-benzodiazepines respectively (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：8047 / 8050

页数：4

共 16 条

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