Brain Malignancy Steering Committee clinical trials planning workshop: Report from the Targeted Therapies Working Group

被引：23

作者：

Alexander, Brian M. ^{[1
]}

Galanis, Evanthia ^{[2
]}

Yung, W. K. Alfred ^{[3
]}

Ballman, Karla V. ^{[2
]}

Boyett, James M. ^{[4
]}

Cloughesy, Timothy F. ^{[5
]}

Degroot, John F. ^{[3
]}

Huse, Jason T. ^{[6
]}

Mann, Bhupinder ^{[7
]}

Mason, Warren ^{[8
]}

Mellinghoff, Ingo K. ^{[6
]}

Mikkelsen, Tom ^{[9
]}

Mischel, Paul S. ^{[10
]}

O'Neill, Brian P. ^{[2
]}

Prados, Michael D. ^{[11
]}

Sarkaria, Jann N. ^{[2
]}

Tawab-Amiri, Abdul ^{[7
]}

Trippa, Lorenzo ^{[1
]}

Ye, Xiaobu ^{[12
]}

Ligon, Keith L. ^{[1
]}

Berry, Donald A. ^{[3
]}

Wen, Patrick Y. ^{[1
]}

机构：

[1] Dana Farber Brigham & Womens Canc Ctr, Boston, MA USA

[2] Mayo Clin, Rochester, MN USA

[3] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[4] St Jude Childrens Res Hosp, Memphis, TN 38105 USA

[5] Univ Calif Los Angeles, Los Angeles, CA USA

[6] Mem Sloan Kettering Canc Ctr, New York, NY 10021 USA

[7] Natl Canc Inst, Bethesda, MD USA

[8] Princess Margaret Canc Ctr, Toronto, ON, Canada

[9] Henry Ford Hosp, Detroit, MI 48202 USA

[10] Univ Calif San Diego, San Diego, CA 92103 USA

[11] Univ Calif San Francisco, San Francisco, CA 94143 USA

[12] Johns Hopkins Univ, Baltimore, MD USA

来源：

NEURO-ONCOLOGY | 2015年 / 17卷 / 02期

关键词：

adaptive randomization; biomarkers; clinical trials; glioblastoma; NEWLY-DIAGNOSED GLIOBLASTOMA; PROGRESSION-FREE SURVIVAL; INTEGRATED GENOMIC ANALYSIS; RANDOMIZED PHASE-III; I-SPY; ISOCITRATE DEHYDROGENASE; ADAPTIVE RANDOMIZATION; ADJUVANT TEMOZOLOMIDE; MUTATIONAL ANALYSIS; TUMOR SAMPLES;

D O I：

10.1093/neuonc/nou154

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Glioblastoma is the most common primary brain malignancy and is associated with poor prognosis despite aggressive local and systemic therapy, which is related to a paucity of viable treatment options in both the newly diagnosed and recurrent settings. Even so, the rapidly increasing number of targeted therapies being evaluated in oncology clinical trials offers hope for the future. Given the broad range of possibilities for future trials, the Brain Malignancy Steering Committee convened a clinical trials planning meeting that was held at the Udvar-Hazy Center in Chantilly, Virginia, on September 19 and 20, 2013. This manuscript reports the deliberations leading up to the event from the Targeted Therapies Working Group and the results of the meeting.

引用

页码：180 / 188

页数：9

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