Comparative in-vitro activity of voriconazole (UK-109,496) and six other antifungal agents against clinical isolates of Scedosporium prolificans and Scedosporium apiospermum

被引：146

作者：

Cuenca-Estrella, M ^{[1
]}

Ruiz-Díez, B ^{[1
]}

Martínez-Suárez, JV ^{[1
]}

Monzón, A ^{[1
]}

Rodríguez-Tudela, JL ^{[1
]}

机构：

[1] Inst Salud Carlos III, Ctr Nacl Microbiol, Unidad Micol, Madrid 28220, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 1999年 / 43卷 / 01期

关键词：

D O I：

10.1093/jac/43.1.149

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

We report the in-vitro susceptibility of 27 clinical isolates of Scedosporium apiospermum and 43 of Scedosporium prolificans. S. apiospermum was resistant to fluconazole and flucytosine, with variable susceptibility to amphotericin B, itraconazole, ketoconazole and susceptible to miconazole. Voriconazole was much more active than fluconazole and flucytosine, more active than amphotericin B, itraconazole and ketoconazole and was as active as miconazole against S. apiospermum isolates. Voriconazole and the other six antifungal agents showed low activity against S. prolificans isolates.

引用

页码：149 / 151

页数：3

共 10 条

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