Two new sesquiterpenoids and anti-HIV principles from the root bark of Zanthoxylum ailanthoides

被引：83

作者：

Cheng, MJ ^{[1
]}

Lee, KH

Tsai, IL

Chen, IS

机构：

[1] Kaohsiung Med Univ, Grad Inst Pharmaceut Sci, Kaohsiung 807, Taiwan

[2] Univ N Carolina, Sch Pharm, Nat Prod Lab, Chapel Hill, NC 27599 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 21期

关键词：

Zanthoxylum ailanthoides; rutaceae; root bark; sesquiterpene; 10; beta-methoxymuurolan-4-en-3-one; alpha-methoxycadinan-4-en-3-one; anti-HIV activity; secarine; gamma-fagarine; (+)-tembamide;

D O I：

10.1016/j.bmc.2005.07.050

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two new sesquiterpenes, 10 beta-methoxymuurolan-4-en-3-one (1) and 10 alpha-methoxycadinan-4-en-3-one (2), were isolated from the root bark of Zanthoxylum ailanthoides. The structures of I and 2 were elucidated from spectroscopic data. Sixty-seven compounds obtained from the root bark of the same plant were evaluated for inhibition of HIV replication in H9 lymphocyte cells, and 14 compounds demonstrated significant activity. Among them, decarine, gamma-fagarine, and (+)-tembamide were the most potent anti-HIV compounds, with EC50 values of < 0.1 mu g/mL and TI values of > 226, > 231, and > 215, respectively, (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：5915 / 5920

页数：6

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