TGFβ signalling in context

被引:2474
作者
Massague, Joan [1 ,2 ]
机构
[1] Mem Sloan Kettering Canc Ctr, Canc Biol & Genet Program, New York, NY 10065 USA
[2] Howard Hughes Med Inst, Chevy Chase, MD 20815 USA
基金
美国国家卫生研究院;
关键词
GROWTH-FACTOR-BETA; BONE MORPHOGENETIC PROTEIN; TO-MESENCHYMAL TRANSITION; BREAST-CANCER CELLS; TUMOR-SUPPRESSOR; UBIQUITIN LIGASE; SMAD PROTEINS; WNT PATHWAYS; TRANSCRIPTIONAL ACTIVATION; MICRORNA MATURATION;
D O I
10.1038/nrm3434
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The basic elements of the transforming growth factor-beta (TGF beta) pathway were revealed more than a decade ago. Since then, the concept of how the TGF beta signal travels from the membrane to the nucleus has been enriched with additional findings, and its multifunctional nature and medical relevance have relentlessly come to light. However, an old mystery has endured: how does the context determine the cellular response to TGF beta? Solving this question is key to understanding TGF beta biology and its many malfunctions. Recent progress is pointing at answers.
引用
收藏
页码:616 / 630
页数:15
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