Patterning a Complex Organ: Branching Morphogenesis and Nephron Segmentation in Kidney Development

被引：506

作者：

Costantini, Frank ^{[1
]}

Kopan, Raphael ^{[2
,3
]}

机构：

[1] Columbia Univ, Dept Genet & Dev, Med Ctr, New York, NY 10032 USA

[2] Washington Univ, Sch Med, Dept Dev Biol, St Louis, MO 63110 USA

[3] Washington Univ, Sch Med, Div Dermatol, St Louis, MO 63110 USA

来源：

DEVELOPMENTAL CELL | 2010年 / 18卷 / 05期

基金：

美国国家卫生研究院;

关键词：

URETERAL BUD MORPHOGENESIS; NOTCH SIGNALING CONTROLS; DEVELOPING MOUSE KIDNEY; PLANAR CELL POLARITY; INTERMEDIATE MESODERM; GENE-EXPRESSION; METANEPHRIC MESENCHYME; MAMMALIAN KIDNEY; EPITHELIAL-CELLS; PROGENITOR CELLS;

D O I：

10.1016/j.devcel.2010.04.008

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The two major components of the kidney, the collecting system and the nephron, have different developmental histories. The collecting system arises by the reiterated branching of a simple epithelial tube, while the nephron forms from a cloud of mesenchymal cells that coalesce into epithelial vesicles. Each develops into a morphologically complex and highly differentiated structure, and together they provide essential filtration and resorption functions. In this review, we will consider their embryological origin and the genes controlling their morphogenesis, patterning, and differentiation, with a focus on recent advances in several areas.

引用

页码：698 / 712

页数：15

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