Multiple roles of ATM in monitoring and maintaining DNA integrity

被引：187

作者：

Derheimer, Frederick A. ^{[1
]}

Kastan, Michael B. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Oncol, Memphis, TN 38105 USA

来源：

FEBS LETTERS | 2010年 / 584卷 / 17期

关键词：

ATM; DNA damage and repair; Ionizing radiation; Chromosomal breakage and instability; Cancer; DOUBLE-STRAND BREAKS; S-PHASE CHECKPOINT; DAMAGE-INDUCED PHOSPHORYLATION; ATAXIA-TELANGIECTASIA CELLS; ACTIVATION IN-VIVO; AUTOPHOSPHORYLATION SITES; IONIZING IRRADIATION; SIGNALING PATHWAYS; CHROMOSOME-DAMAGE; GAMMA-H2AX FOCI;

D O I：

10.1016/j.febslet.2010.05.031

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ability of our cells to maintain genomic integrity is fundamental for protection from cancer development. Central to this process is the ability of cells to recognize and repair DNA damage and progress through the cell cycle in a regulated and orderly manner. In addition, protection of chromosome ends through the proper assembly of telomeres prevents loss of genetic information and aberrant chromosome fusions. Cells derived from patients with ataxia-telangiectasia (A-T) show defects in cell cycle regulation, abnormal responses to DNA breakage, and chromosomal end-to-end fusions. The identification and characterization of the ATM (ataxia-telangiectasia, mutated) gene product has provided an essential tool for researchers in elucidating cellular mechanisms involved in cell cycle control, DNA repair, and chromosomal stability. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：3675 / 3681

页数：7

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