Nanosilver as a new generation of nanoproduct in biomedical applications

被引:1113
作者
Chaloupka, Karla [1 ,4 ]
Malam, Yogeshkumar [1 ]
Seifalian, Alexander M. [1 ,2 ,3 ]
机构
[1] UCL, Ctr Nanotechnol & Regenerat Med, Div Surg & Intervent Sci, London, England
[2] UCL, London Ctr Nanotechnol, London, England
[3] Royal Free Hampstead NHS Trust Hosp, London, England
[4] Univ Zurich Hosp, Dept Ophthalmol, CH-8091 Zurich, Switzerland
基金
英国工程与自然科学研究理事会;
关键词
SILVER NANOPARTICLES SYNTHESIS; NANOCRYSTALLINE SILVER; ANTIBACTERIAL PROPERTIES; ESCHERICHIA-COLI; GREEN SYNTHESIS; INFECTION; CYTOTOXICITY; CATHETERS; WOUNDS; ION;
D O I
10.1016/j.tibtech.2010.07.006
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Nanosilver (NS), comprising silver nanoparticles, is attracting interest for a range of biomedical applications owing to its potent antibacterial activity. It has recently been demonstrated that NS has useful anti-inflammatory effects and improves wound healing, which could be exploited in developing better dressings for wounds and burns. The key to its broad-acting and potent antibacterial activity is the multifaceted mechanism by which NS acts on microbes. This is utilized in antibacterial coatings on medical devices to reduce nosocomial infection rates. Many new synthesis methods have emerged and are being evaluated for NS production for medical applications. NS toxicity is also critically discussed to reflect on potential concerns before widespread application in the medical field.
引用
收藏
页码:580 / 588
页数:9
相关论文
共 80 条
[1]   A prospective double-blinded comparative analysis of framycetin and silver sulphadiazine as topical agents for burns: A pilot study [J].
Ahuja, Rajeev B. ;
Gupta, Amit ;
Gur, Renu .
BURNS, 2009, 35 (05) :672-676
[2]   An in vitro assessment of the antibacterial properties and cytotoxicity of nanoparticulate silver bone cement [J].
Alt, V ;
Bechert, T ;
Steinrücke, P ;
Wagener, M ;
Seidel, P ;
Dingeldein, E ;
Domann, E ;
Schnettler, R .
BIOMATERIALS, 2004, 25 (18) :4383-4391
[3]   Hemocompatibility of diamondlike carbon-metal composite thin films [J].
Andara, Melanie ;
Agarwal, Arvind ;
Scholvin, Dirk ;
Gerhardt, Rosario A. ;
Doraiswamy, Anand ;
Jin, Chunming ;
Narayan, Roger J. ;
Shih, Chun-Che ;
Shih, Chun-Ming ;
Lin, Shing-Jong ;
Su, Yea-Yang .
DIAMOND AND RELATED MATERIALS, 2006, 15 (11-12) :1941-1948
[4]   Toxicity of silver nanoparticles in zebrafish models [J].
Asharani, P. V. ;
Wu, Yi Lian ;
Gong, Zhiyuan ;
Valiyaveettil, Suresh .
NANOTECHNOLOGY, 2008, 19 (25)
[5]   Cytotoxicity and Genotoxicity of Silver Nanoparticles in Human Cells [J].
AshaRani, P. V. ;
Mun, Grace Low Kah ;
Hande, Manoor Prakash ;
Valiyaveettil, Suresh .
ACS NANO, 2009, 3 (02) :279-290
[6]  
ASZ J, 2006, J PEDIATR SURG, V9, pE9
[7]   Effect of silver on burn wound infection control and healing: Review of the literature [J].
Atiyeh, Bishara S. ;
Costagliola, Michel ;
Hayek, Shady N. ;
Dibo, Saad A. .
BURNS, 2007, 33 (02) :139-148
[8]   Prevention of infection in neurosurgery: role of "antimicrobial" catheters [J].
Bayston, Roger ;
Ashraf, Waheed ;
Fisher, Leanne .
JOURNAL OF HOSPITAL INFECTION, 2007, 65 :39-42
[9]   Nanoparticle silver released into water from commercially available sock fabrics [J].
Benn, Troy M. ;
Westerhoff, Paul .
ENVIRONMENTAL SCIENCE & TECHNOLOGY, 2008, 42 (11) :4133-4139
[10]   Intravesical nanocrystalline silver decreases experimental bladder inflammation [J].
Boucher, W. ;
Stern, J. M. ;
Kotsinyan, V. ;
Kempuraj, D. ;
Papaliodis, D. ;
Cohen, M. S. ;
Theoharides, T. C. .
JOURNAL OF UROLOGY, 2008, 179 (04) :1598-1602