CARF Regulates p19ARF-p53-p21WAF1 Senescence Pathway by Multiple Checkpoints

被引：9

作者：

Kaul, Sunil C. ^{[1
]}

Hasan, Kamrul ^{[1
]}

Wadhwa, Renu ^{[1
]}

机构：

[1] Natl Inst Adv Ind Sci & Technol, Gene Funct Res Ctr, Tsukuba, Ibaraki 3058562, Japan

来源：

UNDERSTANDING AND MODULATING AGING | 2006年 / 1067卷

关键词：

CARF (collaborator of ARF); ARF (alternative reading frame protein); p53; interaction; regulation;

D O I：

10.1196/annals.1354.026

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

CARF was first cloned as a novel binding partner of ARF from a yeast-interactive screen. CARF and ARF colocalize in the perinucleolar region and have a collaborative function. In the nucleoplasm, CARF interacts with p53 and enhances its function. We demonstrate that p53 downregulates CARF in a negative feedback regulatory loop and may also involve p53 antagonist HDM2.

引用

页码：217 / 219

页数：3

共 3 条

[1]

Alternative reading frame protein (ARF)-independent function of CARF (collaborator of ARF) involves its interactions with p53: evidence for a novel p53-activation pathway and its negative feedback control [J].

Hasan, MK ;

Yaguchi, T ;

Minoda, Y ;

Hirano, T ;

Taira, K ;

Wadhwa, R ;

Kaul, SC .

BIOCHEMICAL JOURNAL, 2004, 380 :605-610

[2]

CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53 [J].

Hasan, MK ;

Yaguchi, T ;

Sugihara, T ;

Kumar, PKR ;

Taira, K ;

Reddel, RR ;

Kaul, SC ;

Wadhwa, R .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (40) :37765-37770

[3]

A novel putative collaborator of p19ARF [J].

Wadhwa, R ;

Sugihara, T ;

Hasan, MK ;

Duncan, EL ;

Taira, K ;

Kaul, SC .

EXPERIMENTAL GERONTOLOGY, 2003, 38 (03) :245-252

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