Gout

被引:364
作者
Neogi, Tuhina
机构
[1] Boston Univ, Sch Med, Clin Epidemiol Sect, Res & Training Unit, Boston, MA 02118 USA
[2] Boston Univ, Sch Publ Hlth, Dept Epidemiol, Boston, MA 02118 USA
关键词
EVIDENCE BASED RECOMMENDATIONS; URIC-ACID LEVELS; RECURRENT GOUT; DOUBLE-BLIND; INCIDENT GOUT; URATE LEVELS; ACUTE FLARES; TASK-FORCE; PHASE-II; RISK;
D O I
10.1056/NEJMcp1001124
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
A 54-year-old man with crystal-proven gout has a history of four attacks during the previous year. Despite receiving 300 mg of allopurinol daily, his serum urate level is 7.2 mg per deciliter (428 mu mol per liter). He is moderately obese and has hypertension, for which he receives hydrochlorothiazide, and his serum creatinine level is 1.0 mg per deciliter (88 mu mol per liter). How should his case be managed?
引用
收藏
页码:443 / 452
页数:10
相关论文
共 54 条
[1]
Arromdee E, 2002, J RHEUMATOL, V29, P2403
[2]
COMPARISON OF PARENTERAL ADRENOCORTICOTROPIC HORMONE WITH ORAL INDOMETHACIN IN THE TREATMENT OF ACUTE GOUT [J].
AXELROD, D ;
PRESTON, S .
ARTHRITIS AND RHEUMATISM, 1988, 31 (06) :803-805
[3]
Febuxostat compared with allopurinol in patients with hyperuricemia and gout [J].
Becker, MA ;
Schumacher, HR ;
Wortmann, RL ;
MacDonald, PA ;
Eustace, D ;
Palo, WA ;
Streit, J ;
Joseph-Ridge, N .
NEW ENGLAND JOURNAL OF MEDICINE, 2005, 353 (23) :2450-2461
[4]
The urate-lowering efficacy and safety of febuxostat in the treatment of the hyperuricemia of gout: the CONFIRMS trial [J].
Becker, Michael A. ;
Schumacher, H. Ralph ;
Espinoza, Luis R. ;
Wells, Alvin F. ;
MacDonald, Patricia ;
Lloyd, Eric ;
Lademacher, Christopher .
ARTHRITIS RESEARCH & THERAPY, 2010, 12 (02)
[5]
Borstad GC, 2004, J RHEUMATOL, V31, P2429
[6]
Campion E W, 1987, Am J Med, V82, P421, DOI 10.1016/0002-9343(87)90441-4
[7]
Alcohol intake and risk of incident gout in men: a prospective study [J].
Choi, HK ;
Atkinson, K ;
Karlson, EW ;
Willett, W ;
Curhan, G .
LANCET, 2004, 363 (9417) :1277-1281
[8]
Purine-rich foods, dairy and protein intake, and the risk of gout in men [J].
Choi, HK ;
Atkinson, K ;
Karlson, EW ;
Willett, W ;
Curhan, G .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (11) :1093-1103
[9]
Pathogenesis of gout [J].
Choi, HK ;
Mount, DB ;
Reginato, AM .
ANNALS OF INTERNAL MEDICINE, 2005, 143 (07) :499-516
[10]
Soft drinks, fructose consumption, and the risk of gout in men: prospective cohort study [J].
Choi, Hyon K. ;
Curhan, Gary .
BMJ-BRITISH MEDICAL JOURNAL, 2008, 336 (7639) :309-+