Phenotypic and genotypic characterization of macrolide-resistant group A Streptococcus strains in the province of Quebec, Canada

被引：31

作者：

Weiss, K

De Azavedo, J

Restieri, C

Galarneau, LA

Gourdeau, M

Harvey, P

Paradis, JF

Salim, K

Low, DE

机构：

[1] Univ Montreal, Hop Maison Neuve Rosemont, Grp Rech Anti Microbiens, GRAM, Montreal, PQ H1T 2M4, Canada

[2] Univ Toronto, Mt Sinai Hosp, Toronto, ON M5G 1X5, Canada

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2001年 / 47卷 / 03期

关键词：

D O I：

10.1093/jac/47.3.345

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Resistance to macrolides among group A streptococci is an increasing problem worldwide. We examined 496 strains phenotypically and genotypically for resistance to erythromycin and clindamycin. Strains were isolated in five different geographical areas representing about 45% of the total Quebec population. The overall resistance rate was 4.6% but varied from 0% in rural areas to 9.4% in Montreal. Of the 23 strains showing resistance to erythromycin, 15 (65%) had an identical pulsed-field gel electrophoresis pattern, were of serotype M28T28 and harboured the erm(TR) gene, suggesting the spread of a single clone. Of the remaining eight strains, two strains had the erm(B) gene, five had the mef gene and one with a different serotype also had the erm(TR) gene.

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页码：345 / 348

页数：4

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