Epidermal viral immunity induced by CD8α+ dendritic cells but not by Langerhans cells

被引：457

作者：

Allan, RS

Smith, CM

Belz, GT

van Lint, AL

Wakim, LM

Heath, WR ^{[1
]}

Carbone, FR

机构：

[1] Univ Melbourne, Dept Microbiol & Immunol, Melbourne, Vic 3010, Australia

[2] Walter & Eliza Hall Inst Med Res, Div Immunol, Melbourne, Vic 3050, Australia

[3] Walter & Eliza Hall Inst Med Res, Cooperat Res Vaccine Technol, Melbourne, Vic 3050, Australia

来源：

SCIENCE | 2003年 / 301卷 / 5641期

关键词：

D O I：

10.1126/science.1087576

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The classical paradigm for dendritic cell function derives from the study of Langerhans cells, which predominate within skin epidermis. After an encounter with foreign agents, Langerhans cells are thought to migrate to draining lymph nodes, where they initiate T cell priming. Contrary to this, we show here that infection of murine epidermis by herpes simplex virus did not result in the priming of virus-specific cytotoxic T lymphocytes by Langerhans cells. Rather, the priming response required a distinct CD8alpha(+) dendritic cell subset. Thus, the traditional view of Langerhans cells in epidermal immunity needs to be revisited to accommodate a requirement for other dendritic cells in this response.

引用

页码：1925 / 1928

页数：4

共 24 条

[1]

ALLAN RJ, UNPUB

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