Phospholipid liposomes stabilized by the coverage of polyelectrolyte

被引：56

作者：

Ge, LQ

Möhwald, H

Li, JB

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Int Joint Lab, Beijing 100080, Peoples R China

[2] Max Planck Inst Kolloid & Grenzflachenforsch, D-14424 Potsdam, Germany

来源：

COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS | 2003年 / 221卷 / 1-3期

基金：

中国国家自然科学基金;

关键词：

liposomes; TEM; polyelectrolyte adsorption; phospholipids;

D O I：

10.1016/S0927-7757(03)00106-7

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Liposomes of the acidic phospholipid, (L)-alpha-dimyristoylphosphatidic acid (DMPA), were prepared via suitable pH modification of its aqueous solution at 40 degreesC. Transition electron microscopy (TEM) verified the presence of hollow lipid vesicles. Through adsorption of the polyelectrolyte poly(allylamine hydrochloride) (PAH) onto negatively charged DMPA liposomes we found that such surface-modified liposomes cannot be destroyed by the detergent, sodium dodecyl sulfonate (SIDS). Thus polymer-stabilized liposomes are obtained. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：49 / 53

页数：5

共 13 条

[1]

ANILO DL, 1995, CHEM REV, V95, P2601

[2] Giant phospholipid vesicles: comparison among the whole lipid sample characteristics using different preparation methods - A two photon fluorescence microscopy study [J].