Nanoparticlies incorporated in bilaminated films: A smart drug delivery system for oral formulations

被引:34
作者
Cui, Fuying
He, Chunbai
Yin, Lichen
Qian, Feng
He, Miao
Tang, Cui
Yin, Chunhua [1 ]
机构
[1] Fudan Univ, Sch Life Sci, Dept Pharmaceut Sci, State Key Genet Engn, Shanghai 200433, Peoples R China
[2] Fudan Univ, Sch Life Sci, Dept Biochem, Shanghai 200433, Peoples R China
关键词
D O I
10.1021/bm070339e
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A novel smart drug delivery system (NP-Film) consisting of carboxylation chitosan-grafted nanoparticles (CCGNs) and bilaminated films, which were composed of the mucoadhesive chitosan-ethylenedianiinetetraacetic acid hydrogel layer and the hydrophobic ethylcellulose layer, was developed for oral delivery of protein drugs. NP-Film was characterized by electron microscopy and fluorescence microscopy, and the results showed that the solid, spherical nanoparticles dispersed evenly in the porous structures of films. The properties of nanoparticles and films were investigated. The mucoadhesive force, CCGNs released from the NP-Film, and the toxicity of NP-Film were also evaluated. Results showed that the nanoparticles could reversibly open the tight junction of the intestine and inhibit trypsin activity. The release behavior of the nanoparticles from the NP-Film exhibited pH sensitivity. The drug delivery system possessed high mucoadhesive force and low intestinal toxicity. Therefore, the NP-Film would be a promising delivery carrier for protein drugs via oral administration.
引用
收藏
页码:2845 / 2850
页数:6
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