Pallidal stimulation improves pantothenate kinase-associated neurodegeneration

被引:124
作者
Castelnau, P
Cif, L
Valente, EM
Vayssiere, N
Hemm, S
Gannau, A
DiGiorgio, A
Coubes, P
机构
[1] CHU Montpellier, Hop Gui Chauliac, Dept Neurosurg, Res Unit Movement Disorders, Montpellier, France
[2] CHU Tours, Hop Gatien Clocheville, INSERM, UB19, Tours, France
[3] Casa Sollievo Sofferenza, Inst Ricovero & Cura Carattere Sci, San Giovanni Rotondo, Italy
[4] CSS Mendel Inst, Rome, Italy
关键词
D O I
10.1002/ana.20457
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Pantothenate kinase-associated neurodegeneration (PKAN) causes a progressive generalized dystonia which remains pharmacologically intractable. We performed bilateral internal globus pallidus stimulation in six patients with genetically confirmed PKAN who obtained a major and long-lasting improvement of their painful spasms, dystonia, and finictional autonomy. This study shows the benefits of pallidal DBS for the dystonia of PKAN patients.
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页码:738 / 741
页数:4
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