Phosphorelay control of virulence gene expression in Bordetella

被引：150

作者：

Cotter, PA ^{[1
]}

Jones, AM ^{[1
]}

机构：

[1] Univ Calif Santa Barbara, Dept Mol Cellular & Dev Biol, Santa Barbara, CA 93106 USA

来源：

TRENDS IN MICROBIOLOGY | 2003年 / 11卷 / 08期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0966-842X(03)00156-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In Bordetella, the BvgAS phosphorelay comprising the polydomain sensor, BvgS, and response regulator, BvgA, controls the expression of at least three distinct phenotypic phases in response to differences in the concentration of a few chemical compounds. Each phenotypic phase is characterized by maximal expression of some genes and minimal expression of others, and current data support the hypothesis that each plays a distinct and important role in the Bordetella, infectious cycle. The ability to control expression of multiple phenotypic states in response to subtle differences in signal intensity could be a characterizing feature of phosphorelays that contain polydomain sensors.

引用

页码：367 / 373

页数：7

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