The gene encoding p120(cas), a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns)

被引：21

作者：

Reynolds, AB

Jenkins, NA

Gilbert, DJ

Copeland, NG

Shapiro, DN

Wu, J

Daniel, JM

机构：

[1] ST JUDE CHILDRENS RES HOSP, DEPT EXPTL ONCOL, MEMPHIS, TN 38105 USA

[2] NCI, FREDERICK CANC RES & DEV CTR, ABL BASIC RES PROGRAM, MAMMALIAN GENET LAB, FREDERICK, MD 21702 USA

来源：

GENOMICS | 1996年 / 31卷 / 01期

关键词：

D O I：

10.1006/geno.1996.0020

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The p120(cas) gene encodes a protein tyrosine kinase substrate that associates with the cell-cell adhesion protein complex containing E-cadherin and its cytoplasmic cofactors alpha-catenin, beta-catenin, and plakoglobin. Like other components of the cadherin/catenin complex, defects in p120(cas) may contribute to cell malignancy. We have determined the chromosomal location of the p120(cas) gene in human and mouse using fluorescence in situ hybridization and interspecific backcross analysis, respectively. The human p120(cas) gene (CTNND) is localized immediately adjacent to the centromere on the long arm of chromosome 11 in band 11q11. The murine p120(cas) gene (Catns) was assigned to the middle of chromosome 2. Neither locus is currently known to be associated with disease or malignancy. (C) 1996 Academic Press, Inc

引用

页码：127 / 129

页数：3

共 17 条

[1] ISOLATION AND CHARACTERIZATION OF HUMAN CDNA CLONES ENCODING A HIGH MOBILITY GROUP BOX PROTEIN THAT RECOGNIZES STRUCTURAL DISTORTIONS TO DNA CAUSED BY BINDING OF THE ANTICANCER AGENT CISPLATIN [J].