Biosensors based on binding-modulated donor-acceptor distances

被引：126

作者：

Fan, CH ^{[1
]}

Plaxco, KW

Heeger, AJ

机构：

[1] Chinese Acad Sci, Shanghai Inst Appl Phys, Div Nanobiol & Nanomed, Shanghai 201800, Peoples R China

[2] Univ Calif Santa Barbara, Dept Chem & Biochem, Santa Barbara, CA 93106 USA

[3] Univ Calif Santa Barbara, Interdept Biomol Sci & Engn Program, Santa Barbara, CA 93106 USA

[4] Univ Calif Santa Barbara, Inst Polymers & Organ Solids, Santa Barbara, CA 93106 USA

[5] Univ Calif Santa Barbara, Dept Phys, Santa Barbara, CA 93106 USA

[6] Univ Calif Santa Barbara, Dept Mat, Santa Barbara, CA 93106 USA

来源：

TRENDS IN BIOTECHNOLOGY | 2005年 / 23卷 / 04期

关键词：

D O I：

10.1016/j.tibtech.2005.02.005

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The promising recognition characteristics exhibited by biomolecules have caused significant interest in biomolecule-based sensor strategies. Here we review several emerging biosensor designs that use modulated electron or energy transfer to a bio-specific ligand as the signaling mechanism. The efficiencies of both electron transfer and energy transfer are strongly dependent on donor-acceptor distance. When coupled with the large conformational changes sometimes associated with biomolecular recognition, these distance-dependant processes provide a robust means for generating optical and electronic signals.

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页码：186 / 192

页数：7

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