Parathyroid hormone stimulation of noncanonical Wnt signaling in bone

被引：23

作者：

Bergenstock, Marika K. ^{[1
,2
,3
]}

Partridge, Nicola C. ^{[1
,2
]}

机构：

[1] Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Dept Physiol & Biophys, Piscataway, NJ 08854 USA

[2] Grad Sch Biomed Sci, Piscataway, NJ USA

[3] Rutgers State Univ, Dept Biomed Engn, Piscataway, NJ USA

来源：

SKELETAL BIOLOGY AND MEDICINE, PT A: ASPECTS OF BONE MORPHOGENESIS AND REMODELING | 2007年 / 1116卷

关键词：

parathyroid hormone; bone; osteoblasts; Wnt signaling; beta-catenin; Wnt-4; OSTEOGENIC DIFFERENTIATION; BETA-CATENIN; EXPRESSION; PATHWAY; CHONDROGENESIS; OSTEOBLASTS; GENES; CELLS;

D O I：

10.1196/annals.1402.047

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

In bone, parathyroid hormone (PTH) exerts either a catabolic or an anabolic effect depending on its method of administration. This paradoxical action has led to the use of PTH as an effective treatment for osteoporosis. The Wnt family of signaling proteins has a critical role in multiple events, which are necessary for proper animal development and survival, yet their exact method of action in bone remains elusive. We have uncovered a novel link between Wnt-4 and PTH. We think that, in bone, Wnt-4 signaling in response to PTH implicates cross-talk of multiple signaling pathways. This work hopes to further elucidate Wnt signaling in bone and provide greater understanding of PTH's anabolic effects in bone.

引用

页码：354 / 359

页数：6

共 30 条

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