The epidemiology and treatment of ALS: Focus on the heterogeneity of the disease and critical appraisal of therapeutic trials

被引：96

作者：

Beghi, Ettore ^{[1
]}

Chio, Adriano ^{[1
]}

Couratier, Philippe ^{[1
]}

Esteban, Jesus ^{[1
]}

Hardiman, Orla ^{[1
]}

Logroscino, Giancarlo ^{[1
]}

Millul, Andrea ^{[1
]}

Mitchell, Douglas ^{[1
]}

Preux, Pierre-Marie ^{[1
]}

Pupillo, Elisabetta ^{[1
]}

Stevic, Zorica ^{[1
]}

Swingler, Robert ^{[1
]}

Traynor, Bryan J. ^{[1
]}

Van den Berg, Leonard H. ^{[1
]}

Veldink, Jan H. ^{[1
]}

Zoccolella, Stefano ^{[1
]}

机构：

[1] Ist Ric Farmacol Mario Negri, I-20156 Milan, Italy

来源：

AMYOTROPHIC LATERAL SCLEROSIS | 2011年 / 12卷 / 01期

关键词：

Amyotrophic lateral sclerosis; epidemiology; diagnosis; systematic review; treatment; AMYOTROPHIC-LATERAL-SCLEROSIS; CAPTURE-RECAPTURE METHODS; NEURON DISEASE; RATING-SCALE; RELIABILITY; INTERRATER; PREVALENCE;

D O I：

10.3109/17482968.2010.502940

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Effective treatments for amyotrophic lateral sclerosis (ALS) have remained elusive. Only riluzole, a drug thought to affect glutamate metabolism, improves survival albeit to modest extent. Explanations for the negative results of therapeutic trials include a likely heterogeneity, both in disease susceptibility and pathogenic mechanisms, and faulty methodology of clinical trials. Further understanding of these factors will lead to improvements in patient stratification, and in the design of future clinical trials.

引用

页码：1 / 10

页数：10

共 37 条

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INCIDENCE AND PREVALENCE OF AMYOTROPHIC-LATERAL-SCLEROSIS IN HARRIS COUNTY, TEXAS, 1985-1988 [J].