Non-Coding RNA Related to MAPK Signaling Pathway in Liver Cancer

被引：34

作者：

Wang, Qiuxia ^{[1
]}

Feng, Jianguo ^{[2
,3
]}

Tang, Liling ^{[1
]}

机构：

[1] Chongqing Univ, Coll Bioengn, Minist Educ, Key Lab Biorheol Sci & Technol, Chongqing 400044, Peoples R China

[2] Southwest Med Univ, Affiliated Hosp, Dept Anesthesiol, Luzhou 646000, Peoples R China

[3] Southwest Med Univ, Lab Anesthesiol, Luzhou 646000, Peoples R China

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2022年 / 23卷 / 19期

关键词：

non-coding RNA; MAPK signaling pathway; liver cancer; HEPATOCELLULAR-CARCINOMA CELLS; TUMOR-NECROSIS-FACTOR; ACQUIRED-RESISTANCE; INHIBITS MIGRATION; DOWN-REGULATION; UP-REGULATION; PROLIFERATION; ACTIVATION; EXPRESSION; INVASION;

D O I：

10.3390/ijms231911908

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The advancement in high-throughput sequencing analysis and the evaluation of chromatin state maps have revealed that eukaryotic cells produce many non-coding transcripts/RNAs. Further, a strong association was observed between some non-coding RNAs and cancer development. The mitogen-activated protein kinases (MAPK) belong to the serine-threonine kinase family and are the primary signaling pathways involved in cell proliferation from the cell surface to the nucleus. They play an important role in various human diseases. A few non-coding RNAs associated with the MAPK signaling pathway play a significant role in the development of several malignancies, including liver cancer. In this review, we summarize the molecular mechanisms and interactions of microRNA, lncRNA, and other non-coding RNAs in the development of liver cancer that are associated with the MAPK signaling pathway. Further, we briefly discuss the therapeutic strategies for liver cancer related to ncRNA and the MAPK signaling pathway.

引用

页数：22

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