Sepsis Biomarkers in Polytrauma Patients

被引：13

作者：

Adams, Charles A., Jr. ^{[1
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机构：

[1] Rhode Isl Hosp, Div Trauma & Surg Crit Care, Providence, RI 02903 USA

[2] Brown Univ, Warren Alpert Sch Med, Providence, RI 02912 USA

[3] Rhode Isl Hosp, Surg Unit, Providence, RI 02903 USA

[4] Rhode Isl Hosp, Trauma Intens Care Unit, Providence, RI 02903 USA

来源：

CRITICAL CARE CLINICS | 2011年 / 27卷 / 02期

关键词：

Trauma; Biomarker; Sepsis; MULTIPLE ORGAN FAILURE; PANCREATIC STONE PROTEIN; HEMORRHAGIC-SHOCK; PLASMA-CONCENTRATIONS; PROCALCITONIN LEVELS; INJURY SEVERITY; BRAIN INJURY; EARLY MARKER; EARLY IL-6; TRAUMA;

D O I：

10.1016/j.ccc.2010.12.002

中图分类号：

R4 [临床医学];

学科分类号：

100218 [急诊医学];

摘要：

Despite continual advances in medical care and injury prevention efforts, traumatic injury remains a leading cause of death of Americans with these deaths occurring in a tri-modal pattern. The early phases of this pattern are characterized by immune activation whereas the last phase is marked by profound immune dysfunction. It is during this last phase that many trauma patients die of septic complications pointing to a dire need for a specific biomarker for post-traumatic infection. This article discusses several biomarkers, including emerging ones, for infection and sepsis following trauma including inflammatory cytokines, intracellular proteins, and cellular biomarkers.

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页码：345 / +

页数：11

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