Following the molecular pathways toward an understanding of the pathogenesis of systemic sclerosis

被引：244

作者：

Jimenez, SA ^{[1
]}

Derk, CT ^{[1
]}

机构：

[1] Thomas Jefferson Univ, Div Rheumatol, Philadelphia, PA 19107 USA

来源：

ANNALS OF INTERNAL MEDICINE | 2004年 / 140卷 / 01期

关键词：

D O I：

10.7326/0003-4819-140-1-200401060-00010

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review discusses the clinical and physiologic principles of systemic sclerosis, a disease of unknown origin characterized by excessive deposition of Collagen and other connective tissue macromolecules in skin and many internal organs, prominent changes in the microvasculature, and humoral and cellular immunologic abnormalities.

引用

页码：37 / +

页数：86

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