Impairment of olfactory identification ability in individuals at ultra-high risk for psychosis who later develop schizophrenia

被引:153
作者
Brewer, WJ
Wood, SJ
McGorry, PD
Francey, SM
Phillips, LJ
Yung, AR
Anderson, V
Copolov, DL
Singh, B
Velakoulis, D
Pantelis, C
机构
[1] Univ Melbourne, Dept Psychiat, Melbourne, Vic, Australia
[2] Univ Melbourne, Dept Psychol, Melbourne, Vic, Australia
[3] Mental Hlth Res Inst, Appl Schizophrenia Div, Parkville, Vic, Australia
[4] Sunshine Hosp, Cognit Neuropsychiat Res, St Albans, Vic, Australia
[5] Sunshine Hosp, Acad Unit, St Albans, Vic, Australia
[6] ORYGEN Youth Hlth, Youth Program, Personal Assessment & Crisis Evaluat Clin, Parkville, Vic 3052, Australia
关键词
D O I
10.1176/appi.ajp.160.10.1790
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Objective: Previous investigation has revealed stable olfactory identification deficits in neuroleptic-naive patients experiencing a first episode of psychosis, but it is unknown if these deficits predate illness onset. Method: The olfactory identification ability of 81 patients at ultra-high risk for psychosis was examined in relation to that of 31 healthy comparison subjects. Twenty-two of the ultra-high-risk patients (27.2%) later became psychotic, and 12 of these were diagnosed with a schizophrenia spectrum disorder. Results: There was a significant impairment in olfactory identification ability in the ultra-high-risk group that later developed a schizophrenia spectrum disorder but not in any other group. Conclusions: These findings suggest that impairment of olfactory identification is a premorbid marker of transition to schizophrenia, but it is not predictive of psychotic illness more generally.
引用
收藏
页码:1790 / 1794
页数:5
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