Cognitive Impairment Questionnaire (CIMP-QUEST): reported topographic symptoms in MCI and dementia

被引:15
作者
Astrand, R. [1 ]
Rolstad, S. [2 ]
Wallin, A. [2 ]
机构
[1] Cent Hosp Karlstad, Karlstad, Sweden
[2] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Gothenburg, Sweden
来源
ACTA NEUROLOGICA SCANDINAVICA | 2010年 / 121卷 / 06期
基金
英国医学研究理事会;
关键词
brain regional; dementia; informant; MCI; questionnaire; validation; INFORMANT QUESTIONNAIRE; ALZHEIMERS-DISEASE; ELDERLY IQCODE; DECLINE; RELIABILITY; VALIDITY; SCALE; MILD;
D O I
10.1111/j.1600-0404.2009.01312.x
中图分类号
R74 [神经病学与精神病学];
学科分类号
100204 [神经病学];
摘要
Objective - The Cognitive Impairment Questionnaire (CIMP-QUEST) is an instrument based on information obtained by key informants to identify symptoms of dementia and dementia-like disorders. The questionnaire consists of three subscales reflecting impairment in parietal-temporal (PT), frontal (F) and subcortical (SC) brain regions. The questionnaire includes a memory scale and lists non-cognitive symptoms. The reliability and validity of the questionnaire were examined in 131 patients with mild cognitive impairment (MCI) or mild dementia at a university-based memory unit. Methods/Results - Cronbach alpha for all subscales was calculated at r = 0.90. Factor analysis supported the tri-dimensionality of CIMP-QUEST's brain region-oriented construct. Test-retest reliability for a subgroup of cognitively stable MCI-patients (n = 25) was found to be r = 0.83 (P = 0.0005). The correlation between the score on the cognitive subscales (PT + F + M) and Informant Questionnaire on Cognitive Decline in the Elderly was r = 0.83 (P = 0.0005, n = 123). The memory subscale correlated significantly with episodic memory tests, the PT subscale with visuospatial and language-oriented tests, and the SC and F subscales with tests of attention, psychomotor tempo and executive function. Conclusions - CIMP-QUEST has high reliability and validity, and provides information about cognitive impairment and brain region-oriented symptomatology in patients with MCI and mild dementia.
引用
收藏
页码:384 / 391
页数:8
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