Iridium-Difluorphos-Catalyzed Asymmetric Hydrogenation of 2-Alkyl- and 2-Aryl-Substituted Quinoxalines: A General and Efficient Route into Tetrahydroquinoxalines

被引：73

作者：

Cartigny, Damien ^{[2
]}

Nagano, Takuto ^{[1
]}

Ayad, Tahar ^{[2
]}

Genet, Jean-Pierre ^{[2
]}

Ohshima, Takashi ^{[1
]}

Mashima, Kazushi ^{[1
]}

Ratovelomanana-Vidal, Virginie ^{[2
]}

机构：

[1] Osaka Univ, Dept Chem, Grad Sch Engn Sci, Osaka 5608631, Japan

[2] Ecole Natl Super Chim Paris, CNRS, Lab Charles Friedel, UMR 7223, F-75231 Paris 05, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2010年 / 352卷 / 11-12期

关键词：

asymmetric catalysis; difluorphos; hydrogenation; iridium; quinoxaline; tetrahydroquinoxalines; ENANTIOSELECTIVE HYDROGENATION; O-PHENYLENEDIAMINES; DIPHOSPHINE LIGAND; COMPLEXES; IMINES; DERIVATIVES; ANTAGONISTS; INHIBITORS; DESIGN; POTENT;

D O I：

10.1002/adsc.201000513

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A highly efficient and general iridium-difluorphos-catalyzed asymmetric hydrogenation of diverse 2-alkyl- and 2-aryl-substituted quinoxalines into biologically and pharmaceutically relevant 2-substituted-1,2,3,4-tetrahydroquinoxaline units has been developed. High isolated yields and excellent enantioselectivities of up to 95% for 2-alkyl-substituted quinoxalines and of up to 94% for 2-aryl-substituted quinoxalines were obtained.

引用

页码：1886 / 1891

页数：6

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