Fornix-dependent induction of hippocampal CCAAT enhancer-binding protein β and δ co-localizes with phosphorylated cAMP response element-binding protein and accompanies long-term memory consolidation

被引:141
作者
Taubenfeld, SM
Wiig, KA
Monti, B
Dolan, B
Pollonini, G
Alberini, CM
机构
[1] Brown Univ, Dept Neurosci, Providence, RI 02912 USA
[2] Brown Univ, Howard Hughes Med Inst, Providence, RI 02912 USA
关键词
C/EBP; CREB; learning and memory; inhibitory avoidance; fornix; lesion; hippocampus; rat;
D O I
10.1523/JNEUROSCI.21-01-00084.2001
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The cAMP response element-binding protein (CREB) is an evolutionarily conserved transcription regulator essential for longterm memory formation. It is not known, however, whether the molecular events downstream of CREB activation are also conserved. An early, cAMP-dependent event necessary for learning-related long-term synaptic plasticity in the invertebrate Aplysia californica is the induction of the transcription factor CCAAT enhancer-binding protein (C/EBP). Here we show that two homologs in the rat, C/EBP beta and C/EBP delta, are induced at discrete times after inhibitory avoidance learning and colocalize with phosphorylated CREB in the hippocampus. This induction is blocked by fornix lesions, which are known to disrupt activation of CREB in the hippocampus and to impair memory consolidation. These results indicate that C/EBPs are evolutionarily conserved components of the CREB-dependent gene cascade activated in long-term memory.
引用
收藏
页码:84 / 91
页数:8
相关论文
共 56 条
  • [1] The relationships between temporal lobe and diencephalic structures implicated in anterograde amnesia
    Aggleton, JP
    Saunders, RC
    [J]. MEMORY, 1997, 5 (1-2) : 49 - 71
  • [2] MEMORY FIXATION IN GOLDFISH
    AGRANOFF, BW
    DAVIS, RE
    BRINK, JJ
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1965, 54 (03) : 788 - &
  • [3] C/EBP IS AN IMMEDIATE-EARLY GENE REQUIRED FOR THE CONSOLIDATION OF LONG-TERM FACILITATION IN APLYSIA
    ALBERINI, CM
    GHIRARDI, M
    METZ, R
    KANDEL, ER
    [J]. CELL, 1994, 76 (06) : 1099 - 1114
  • [4] Barondes S.H., 1975, Short Term Memory, P379
  • [5] APLYSIA CREB2 REPRESSES LONG-TERM FACILITATION - RELIEF OF REPRESSION CONVERTS TRANSIENT FACILITATION INTO LONG-TERM FUNCTIONAL AND STRUCTURAL-CHANGE
    BARTSCH, D
    GHIRARDI, M
    SKEHEL, PA
    KARL, KA
    HERDER, SP
    CHEN, M
    BAILEY, CH
    KANDEL, ER
    [J]. CELL, 1995, 83 (06) : 979 - 992
  • [6] CREB1 encodes a nuclear activator, a repressor, and a cytoplasmic modulator that form a regulatory unit critical for long-term facilitation
    Bartsch, D
    Casadio, A
    Karl, KA
    Serodio, P
    Kandel, ER
    [J]. CELL, 1998, 95 (02) : 211 - 223
  • [7] Involvement of hippocampal cAMP/cAMP-dependent protein kinase signaling pathways in a late memory consolidation phase of aversively motivated learning in rats
    Bernabeu, R
    Bevilaqua, L
    Ardenghi, P
    Bromberg, E
    Schmitz, P
    Bianchin, M
    Izquierdo, I
    Medina, JH
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (13) : 7041 - 7046
  • [8] Drugs acting upon the cyclic adenosine monophosphate protein kinase A signalling pathway modulate memory consolidation when given late after training into rat hippocampus but not amygdala
    Bevilaqua, L
    Ardenghi, P
    Schroder, N
    Bromberg, E
    Schmitz, PK
    Schaeffer, E
    Quevedo, J
    Bianchin, M
    Walz, R
    Medina, JH
    Izquierdo, I
    [J]. BEHAVIOURAL PHARMACOLOGY, 1997, 8 (04): : 331 - 338
  • [9] Bourtchouladze R, 1998, LEARN MEMORY, V5, P365
  • [10] DEFICIENT LONG-TERM-MEMORY IN MICE WITH A TARGETED MUTATION OF THE CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN
    BOURTCHULADZE, R
    FRENGUELLI, B
    BLENDY, J
    CIOFFI, D
    SCHUTZ, G
    SILVA, AJ
    [J]. CELL, 1994, 79 (01) : 59 - 68