Siberian ginseng reduces infarct volume in transient focal cerebral ischaemia in Sprague-Dawley rats

被引：38

作者：

Bu, YM

Jin, ZH

Park, SY

Baek, SY

Rho, SJ

Ha, N

Park, SK

Kim, SY

Kim, HC

机构：

[1] Kyung Hee Univ, Grad Sch E W Med Sci, Dept Herbal Pharmacol, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Oriental Med, Dept Prescriptionol, Seoul 130701, South Korea

[3] Kyung Hee Univ, Coll Oriental Med, Dept Herbal Pharmacol, Seoul 130701, South Korea

来源：

PHYTOTHERAPY RESEARCH | 2005年 / 19卷 / 02期

关键词：

neuroprotection; focal ischaemia; acanthopanax senticosus; Siberian ginseng; traditional Korean medicine;

D O I：

10.1002/ptr.1649

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Siberian ginseng, the root and stem bark of Acanthopanax senticosus Harms, has been used as a tonic and adaptogen to strengthen qi in traditional Korean medicine. The neuroprotective effects of water extracts of A. senticosus (ASW) were investigated in transient middle cerebral artery occlusion (MCAo, 90 min occlusion, 24 h reperfusion) of Sprague-Dawley rats. The infarct volume was significantly reduced by 36.6% after the peritoneal injection of ASW (100 mg/kg) compared with the control. In the immunohistochemical study, ASW markedly inhibited both cyclooxygenase-2 and OX-42 expressions in the penumbral region at 24 It after MCAo. These results suggest that A. senticosus has a neuroprotective effect by inhibiting inflammation and microglial activation in brain ischaemia. Copyright (c) 2005 John Wiley & Sons, Ltd.

引用

页码：167 / 169

页数：3

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