The autoimmune disease-associated IL12B and IL23R polymorphisms in multiple sclerosis

被引：30

作者：

Begovich, Ann B. ^{[2
]}

Chang, Monica ^{[2
]}

Caillier, Stacy J. ^{[1
]}

Lew, David ^{[2
]}

Catanese, Joseph J. ^{[2
]}

Wang, Joanne ^{[1
]}

Hauser, Stephen L. ^{[1
]}

Oksenberg, Jorge R. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Neurol, San Francisco, CA 94143 USA

[2] Celera, Alameda, CA USA

来源：

HUMAN IMMUNOLOGY | 2007年 / 68卷 / 11期

关键词：

family-based genetic association; IL12B gene; IL23R gene; multiple sclerosis; transmission disequilibrium test;

D O I：

10.1016/j.humimm.2007.09.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recently published genetic studies in psoriasis, inflammatory bowel disease, and ankylosing spondylitis identified significant associations with IL12B and IL23R polymorphisms. An important rote for the IL-12/IL-23 pathway in multiple sclerosis (MS) is supported by immunologic studies in patients and animal models. To determine whether IL12B/IL23R disease-associated polymorphisms play a rote in susceptibility to MS, we genotyped 910MS-nuclear-families, totaling 3132 individuals. Family-based association analysis was performed. There was no evidence of transmission distortion of any of the tested alleles in this data set. (c) 2007 American Society for Histocompatibility and Immunogenetics. Published by Elsevier Inc. All rights reserved.

引用

页码：934 / 937

页数：4

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