Design and synthesis of analogs of vitamin E: Antiproliferative activity against human breast adenocarcinoma cells

被引：27

作者：

Arya, P

Alibhai, N

Qin, H

Burton, GW

Batist, G

You, SXL

Alaoui-Jamali, MA

机构：

[1] Natl Res Council Canada, Steacie Inst Mol Sci, Ottawa, ON, Canada

[2] McGill Univ, McGill Ctr Translat Res Canc, Montreal, PQ, Canada

[3] McGill Univ, Sir Mortimer Jewish Gen Hosp, Lady Davis Inst, Montreal, PQ, Canada

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 18期

基金：

加拿大自然科学与工程研究理事会;

关键词：

D O I：

10.1016/S0960-894X(98)00438-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Analogs of alpha-tocopherol (vitamin E; compounds 3-9) have been synthesized and tested for their antiproliferative activity using the human breast cancer cell line, MCF7. Compounds 6-9 were synthesized from a common synthon, rac-Trolox (14) and are soluble/miscible at physiological pH. Compounds 4, 8, and 9 were found to have antiproliferative activity at micromolar concentrations. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2433 / 2438

页数：6

共 13 条

[1] RADIATION-INDUCED DAMAGE TO DNA IN DRUG-RESISTANT AND RADIATION-RESISTANT SUBLINES OF A HUMAN BREAST-CANCER CELL-LINE [J].