Oxidative folding of proteins

被引：185

作者：

Narayan, M ^{[1
]}

Welker, E ^{[1
]}

Wedemeyer, WJ ^{[1
]}

Scheraga, HA ^{[1
]}

机构：

[1] Cornell Univ, Baker Lab Chem & Chem Biol, Ithaca, NY 14853 USA

来源：

ACCOUNTS OF CHEMICAL RESEARCH | 2000年 / 33卷 / 11期

关键词：

D O I：

10.1021/ar000063m

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The oxidative folding of proteins is reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). The mutual effects of conformational folding and disulfide bond regeneration are emphasized, particularly the "locking in" of native disulfide bonds by stable tertiary structure in disulfide intermediates. Two types of structured metastable disulfide species are discerned, depending on the relative protection of their disulfide bonds and thiol groups. Four generic pathways for oxidative folding are identified and characterized.

引用

页码：805 / 812

页数：8

共 52 条

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