Clozapine and olanzapine treatment decreases rat cortical and limbic GABAA receptors

被引：56

作者：

Farnbach-Pralong, D ^{[1
]}

Bradbury, R ^{[1
]}

Copolov, D ^{[1
]}

Dean, B ^{[1
]}

机构：

[1] Mental Hlth Res Inst, Mol Schizophrenia Div, Rebecca L Cooper Res Labs, Parkville, Vic 3052, Australia

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1998年 / 349卷 / 2-3期

关键词：

antipsychotic; GABA (gamma-aminobutyric acid); schizophrenia;

D O I：

10.1016/S0014-2999(98)00285-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The density of GABA(A) receptors in the hippocampus and the temporal cortex from rats treated for 28 days with either haloperidol, chlorpromazine, clozapine or olanzapine was measured. Compared to haloperidol (0.01 and 0.1 mg kg(-1) day-(1)) and chlorpromazine (0.1 and 1 mg kg(-1) day(-1)), clozapine and olanzapine (0.1 and 1 mg kg(-1) day(-1)) markedly decreased the density of GABA(A) receptors in these two brain regions. These data suggest that modulation of GABAergic transmission could be an important action of some antipsychotic drugs. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：R7 / R8

页数：2

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