Comparative map between chicken Chromosome 15 and human chromosomal region 12q24 and 22q11-q12

被引：12

作者：

Jennen, DGJ ^{[1
]}

Crooijmans, RPMA ^{[1
]}

Kamps, B ^{[1
]}

Açar, R ^{[1
]}

van der Poel, JJ ^{[1
]}

Groenen, MAM ^{[1
]}

机构：

[1] Univ Wageningen & Res Ctr, Wageningen Inst Anim Sci, Anim Breeding & Genet Grp, NL-6709 PG Wageningen, Netherlands

来源：

MAMMALIAN GENOME | 2003年 / 14卷 / 09期

关键词：

D O I：

10.1007/s00335-003-3007-z

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The physical and comparative map of GGA15 was improved by the construction of 9 BAC contigs around loci previously mapped on GGA15 by linkage analysis. In total, 240 BAC clones were isolated, covering 30-35% of GGA15, and 120 STS were developed (104 STS derived from BAC end sequences and 18 STS derived within genes). Seventeen chicken orthologues of human genes located on human Chr 22q11-q12 were directly mapped within BAC contigs of GGA15. Furthermore, the partial sequences of the chicken BAC clones were compared with sequences present in the EMBL/GenBank databases and revealed matches to 26 genes, ESTs, and genomic clones located on HSA22q11-q12 and HSA12q24. These results provide a better alignment of GGA15 with the corresponding regions in human and mouse, and improve our knowledge of the evolution and dynamics of the vertebrate genome.

引用

页码：629 / 639

页数：11

共 21 条

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