Studies on the phosphorylation of LY303366

被引：6

作者：

Udodong, UE ^{[1
]}

Turner, WW ^{[1
]}

Astleford, BA ^{[1
]}

Brown, F ^{[1
]}

Clayton, MT ^{[1
]}

Dunlap, SE ^{[1
]}

Frank, SA ^{[1
]}

Grutsch, JL ^{[1
]}

LaGrandeur, LM ^{[1
]}

Verral, DE ^{[1
]}

Werner, JA ^{[1
]}

机构：

[1] Eli Lilly & Co, Lilly Corp Ctr, Lilly Res Labs, Indianapolis, IN 46285 USA

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 34期

关键词：

D O I：

10.1016/S0040-4039(98)01294-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Phosphorylation of LY303366 (1) was studied in THF and DMF. Benzyl phosphate 2 could be prepared in excellent yield using LiOH as the base. Both 2 and the derived phosphonic acid monosodium salt 3 were prone to undergo hydrolytic dephosphorylation. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：6115 / 6118

页数：4

共 6 条

[1] SYNTHESIS, STABILITY, AND BIOLOGICAL EVALUATION OF WATER-SOLUBLE PRODRUGS OF A NEW ECHINOCANDIN LIPOPEPTIDE - DISCOVERY OF A POTENTIAL CLINICAL AGENT FOR THE TREATMENT OF SYSTEMIC CANDIDIASIS AND PNEUMOCYSTIS-CARINII PNEUMONIA (PCP) [J].

BALKOVEC, JM ;

BLACK, RM ;

HAMMOND, ML ;

HECK, JV ;

ZAMBIAS, RA ;

ABRUZZO, G ;

BARTIZAL, K ;

KROPP, H ;

TRAINOR, C ;

SCHWARTZ, RE ;

MCFADDEN, DC ;

NOLLSTADT, KH ;

PITTARELLI, LA ;

POWLES, MA ;

SCHMATZ, DM .

JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (01) :194-198

[2] SEMISYNTHETIC CHEMICAL MODIFICATION OF THE ANTIFUNGAL LIPOPEPTIDE ECHINOCANDIN-B (ECB) - STRUCTURE-ACTIVITY STUDIES OF THE LIPOPHILIC AND GEOMETRIC PARAMETERS OF POLYARYLATED ACYL ANALOGS OF ECB [J].

DEBONO, M ;

TURNER, WW ;

LAGRANDEUR, L ;

BURKHARDT, FJ ;

NISSEN, JS ;

NICHOLS, KK ;

RODRIGUEZ, MJ ;

ZWEIFEL, MJ ;

ZECKNER, DJ ;

GORDEE, RS ;

TANG, J ;

PARR, TR .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (17) :3271-3281

[3]

DEBONO M, 1994, EXPERT OPIN INV DRUG, V3, P821

[4]

KHORANA HG, 1953, J AM CHEM SOC, V75, P2257

[5]

Smith M., 1961, BIOCH PREP, V8, P130

[6]

Turner WW, 1996, CURR PHARM DESIGN, V2, P209

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