The metastasis associated protein S100A4: role in tumour progression and metastasis

被引：191

作者：

Helfman, DM ^{[1
]}

Kim, EJ

Lukanidin, E

Grigorian, M

机构：

[1] Univ Miami, Sch Med, Dept Cell Biol & Anat, Sylvester Comprehens Canc Ctr, Miami, FL 33136 USA

[2] SUNY Stony Brook, Dept Genet, Stony Brook, NY 11794 USA

[3] Danish Canc Soc, Inst Canc Biol, Dept Mol Canc Biol, DK-2100 Copenhagen, Denmark

来源：

BRITISH JOURNAL OF CANCER | 2005年 / 92卷 / 11期

关键词：

breast cancer; prognosis; motility; invasion; apoptosis; angiogenesis;

D O I：

10.1038/sj.bjc.6602613

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The metastasis associated protein S100A4 is a small calcium binding protein that is associated with metastatic tumors and appears to be a molecular marker for clinical prognosis. Below we discuss its biochemical properties and possible cellular functions in metastasis including cell motility, invasion, apoptosis, angiogenesis and differentiation.

引用

页码：1955 / 1958

页数：4

共 41 条

[1] The metastasis-associated Mts1(S100A4) protein could act as an angiogenic factor [J].

Ambartsumian, N ;

Klingelhöfer, J ;

Grigorian, M ;

Christensen, C ;

Kriajevska, M ;

Tulchinsky, E ;

Georgiev, G ;

Berezin, V ;

Bock, E ;

Rygaard, J ;

Cao, RH ;

Cao, YH ;

Lukanidin, E .

ONCOGENE, 2001, 20 (34) :4685-4695

[2]

Ambartsumian NS, 1996, ONCOGENE, V13, P1621

[3] Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton [J].

Belot, N ;

Pochet, R ;

Heizmann, CW ;

Kiss, R ;

Decaestecker, C .

BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS, 2002, 1600 (1-2) :74-83

[4]

Bjornland K, 1999, CANCER RES, V59, P4702

[5] Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka) [J].

Chen, HL ;

Fernig, DG ;

Rudland, PS ;

Sparks, A ;

Wilkinson, MC ;

Barraclough, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2001, 286 (05) :1212-1217

[6] Overexpression of S100A4 is closely related to the aggressiveness of gastric cancer [J].

Cho, YG ;

Nam, SW ;

Kim, TY ;

Kim, YS ;

Kim, CJ ;

Park, JY ;

Lee, JH ;

Kim, HS ;

Lee, JW ;

Park, CH ;

Song, YH ;

Lee, SH ;

Yoo, NJ ;

Lee, JY ;

Park, WS .

APMIS, 2003, 111 (05) :539-545

[7] Differential proteomic analysis of human hepatocellular carcinoma cell line metastasis-associated proteins [J].

Cui, JF ;

Liu, YK ;

Pan, BS ;

Song, HY ;

Zhang, Y ;

Sun, RX ;

Chen, J ;

Feng, JT ;

Tang, ZY ;

Yu, YL ;

Shen, HL ;

Yang, PY .

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY, 2004, 130 (10) :615-622

[8]

Davies MPA, 1996, ONCOGENE, V13, P1631

[9]

DAVIS CL, 1993, MATER SCI TECH SER, V9, P8, DOI 10.1179/026708393790171494

[10] ISOLATION AND CHARACTERIZATION OF A GENE SPECIFICALLY EXPRESSED IN DIFFERENT METASTATIC CELLS AND WHOSE DEDUCED GENE-PRODUCT HAS A HIGH DEGREE OF HOMOLOGY TO A CA-2+-BINDING PROTEIN FAMILY [J].

EBRALIDZE, A ;

TULCHINSKY, E ;

GRIGORIAN, M ;

AFANASYEVA, A ;

SENIN, V ;

REVAZOVA, E ;

LUKANIDIN, E .

GENES & DEVELOPMENT, 1989, 3 (07) :1086-1093

← 1 2 3 4 5 →