Molecular mechanisms in lymphocyte activation and growth

被引：16

作者：

Ballard, DW ^{[1
]}

机构：

[1] Vanderbilt Univ, Sch Med, Dept Microbiol & Immunol, Nashville, TN 37232 USA

来源：

IMMUNOLOGIC RESEARCH | 2001年 / 23卷 / 2-3期

关键词：

NF-kappa B; lymphocyte; retrovirus; signal transduction; gene expression;

D O I：

10.1385/IR:23:2-3:157

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Transcription factor NF-kappaB is biochemically coupled to the T cell antigen receptor (TCR) and activated transiently during an adaptive immune response. The author's laboratory is investigating the signal dependent regulation of NF-kappaB, its downstream gene targets, and its function in lymphocyte biology. Our studies have revealed novel enzymatic checkpoints in the NF-kappaB signaling pathway and constitutive repressors of NF-kappaB that might be clinically applicable for therapeutic control of the immune system. We have also found that the Tax transforming protein encoded by human T cell leukemia virus type I (HTLV1)binds to and persistently activates an inducible protein kinase in the TCR/NF-kappaB axis. This viral/host interaction appears to trigger the inappropriate expression of NF-kappaH and the development of HTLV I-associated disease.

引用

页码：157 / 166

页数：10

共 58 条

[1] NF-kappa B: Ten years after [J].

Baeuerle, PA ;

Baltimore, D .

CELL, 1996, 87 (01) :13-20

[2]

BAEUERLE PA, 1994, ANNU REV IMMUNOL, V12, P141, DOI 10.1146/annurev.immunol.12.1.141

[3] I-KAPPA-B - A SPECIFIC INHIBITOR OF THE NF-KAPPA-B TRANSCRIPTION FACTOR [J].

BAEUERLE, PA ;

BALTIMORE, D .

SCIENCE, 1988, 242 (4878) :540-546

[4] The NF-kappa B and I kappa B proteins: New discoveries and insights [J].

Baldwin, AS .

ANNUAL REVIEW OF IMMUNOLOGY, 1996, 14 :649-683

[5] HTLV-1 TAX INDUCES CELLULAR PROTEINS THAT ACTIVATE THE KAPPA-B ELEMENT IN THE IL-2 RECEPTOR ALPHA-GENE [J].

BALLARD, DW ;

BOHNLEIN, E ;

LOWENTHAL, JW ;

WANO, Y ;

FRANZA, BR ;

GREENE, WC .

SCIENCE, 1988, 241 (4873) :1652-1655

[6] THE 65-KDA SUBUNIT OF HUMAN NF-KAPPA-B FUNCTIONS AS A POTENT TRANSCRIPTIONAL ACTIVATOR AND A TARGET FOR V-REL-MEDIATED REPRESSION [J].

BALLARD, DW ;

DIXON, EP ;

PEFFER, NJ ;

BOGERD, H ;

DOERRE, S ;

STEIN, B ;

GREENE, WC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (05) :1875-1879

[7] Control of apoptosis by Rel/NF-κB transcription factors [J].

Barkett, M ;

Gilmore, TD .

ONCOGENE, 1999, 18 (49) :6910-6924

[8] THE I-KAPPA-B PROTEINS - MULTIFUNCTIONAL REGULATORS OF REL/NF-KAPPA-B TRANSCRIPTION FACTORS [J].

BEG, AA ;

BALDWIN, AS .

GENES & DEVELOPMENT, 1993, 7 (11) :2064-2070

[9] An intact NF-κB signaling pathway is required for maintenance of mature B cell subsets [J].

Bendall, HH ;

Sikes, ML ;

Ballard, DW ;

Oltz, EM .

MOLECULAR IMMUNOLOGY, 1999, 36 (03) :187-195

[10] Transcription factor NF-kappa B regulates inducible Oct-2 gene expression in precursor B lymphocytes [J].

Bendall, HH ;

Scherer, DC ;

Edson, CR ;

Ballard, DW ;

Oltz, EM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (46) :28826-28828

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