Research on antifungal and antimycobacterial agents. Synthesis and activity of 4-alkylthiopyridine-2-carbothioamides

被引：19

作者：

Klimesova, V

Svoboda, M

Waisser, K

Machacek, M

Buchta, V

Odlerova, Z

机构：

[1] FAC PHARM,DEPT BIOL & MED SCI,HRADEC KRALOVE 50005,CZECH REPUBLIC

[2] INST PREVENT & CLIN MED,BRATISLAVA 83301,SLOVAKIA

来源：

ARCHIV DER PHARMAZIE | 1996年 / 329卷 / 10期

关键词：

4-alkylthiopyridine-2-carbothioamides; antimycobacterial activity; antifungal activity; structure-activity relationships;

D O I：

10.1002/ardp.19963291003

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 4-alkylthiopyridine-2-carbothioamides have been prepared and evaluated in vitro for antimicrobial activity. Chemical structures have been demonstrated by IR and H-1 NMR data and by elemental analysis. The antimycobacterial activity of these compounds against Mycobacterium tuberculosis, Mycobacterium kansasii, Mycobacterium avium, and Mycobacterium fortuitum, and the antifungal activity against Candida albicans, Candida tropicalis, Candida krusei, Candida glabrata, Trichosporon beigelii, Trichophyton mentagrophytes, Aspergillus fumigatus, and Absidia corymbifera were determined by the MIC values. Compounds 3 exhibit good antimycobacterial activity compared to isoniazide. A moderate antifungal activity was observed against T. mentagrophytes. Activity is influenced by hydrophobicity of the alkyl group.

引用

页码：438 / 442

页数：5

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