Targeting extrinsic apoptosis in cancer: Challenges and opportunities

被引：92

作者：

Fulda, Simone ^{[1
,2
,3
]}

机构：

[1] Goethe Univ Frankfurt, Inst Expt Canc Res Pediat, D-60528 Frankfurt, Germany

[2] German Canc Consortium DKTK, Heidelberg, Germany

[3] German Canc Res Ctr, Heidelberg, Germany

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2015年 / 39卷

关键词：

Apoptosis; Cancer; TRAIL; Caspase-8; TRAIL-INDUCED APOPTOSIS; LIGAND-INDUCED APOPTOSIS; MEDIATED UP-REGULATION; BREAST-TUMOR CELLS; DEATH RECEPTOR; INTERFERON-GAMMA; NEUROBLASTOMA-CELLS; CASPASE-8; EXPRESSION; INHIBITORS SENSITIZE; DOWN-REGULATION;

D O I：

10.1016/j.semcdb.2015.01.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Apoptosis is a form of programmed cell death that plays a critical role in the regulation of various physiological and pathophysiological processes. Since apoptosis is typically disturbed in human cancers, therapeutic targeting of apoptosis represents a promising avenue for the development of novel therapeutic approaches. This strategy is particularly relevant, since many currently used anticancer therapies utilize apoptosis signaling pathways to exert their antitumor activities. A better understanding of these signaling networks and their deregulation in human cancers is anticipated to open new perspectives for the development of apoptosis-targeted therapies for the treatment of cancer. (C) 2015 Elsevier Ltd. All rights reserved.

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页码：20 / 25

页数：6

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