Glutathione S-transferase mu (GST mu) deficiency and DNA adducts in lymphocytes of smokers

被引：21

作者：

Soni, M ^{[1
]}

Madurantakan, M ^{[1
]}

Krishnaswamy, K ^{[1
]}

机构：

[1] Indian Council Med Res, Natl Inst Nutr, Food & Drug Toxicol Res Ctr, Hyderabad 500007, Andhra Pradesh, India

来源：

TOXICOLOGY | 1998年 / 126卷 / 03期

关键词：

cigarette smoking; DNA adduct formation; lymphocytes; glutathione S-transferase (class Mu);

D O I：

10.1016/S0300-483X(98)00010-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The effect of smoking on DNA adduct formation in lymphocytes was analysed in individuals with low (deficient) and high (non-deficient) glutathione S-transferase (class Mu) activity. DNA adduct levels in lymphocytes were determined by the highly sensitive nuclease Pl-enhanced P-32-postlabeling assay. The lymphocyte DNA adducts/10(8) nucleotides of smokers deficient in glutathione S-transferase Mu activity (n = 12) were significantly higher than those of smokers non-deficient (n = 9) in glutathione S-transferase Mu activity. The DNA adduct levels of the lymphocytes inversely correlated with glutathione S-transferase Mu activity. A correlation was found between DNA adduct levels and daily cigarette consumption. Results of the present study suggest that individuals deficient in glutathione S-transferase Mu activity may be at greater risk of DNA damage. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：155 / 162

页数：8

共 32 条

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