F1-ATPase is a highly efficient molecular motor that rotates with discrete 120° steps

被引：666

作者：

Yasuda, R

Noji, H

Kinosita, K ^{[1
]}

Yoshida, M

机构：

[1] Keio Univ, Fac Sci & Technol, Dept Phys, Yokohama, Kanagawa 2238522, Japan

[2] Tokyo Inst Technol, Resources Utilizat Res Lab, Yokohama, Kanagawa 2268503, Japan

[3] Teikyo Univ, Biotechnol Res Ctr 3F, CREST Genet Programming Team 13, Miyamae Ku, Kawasaki, Kanagawa 2160001, Japan

来源：

CELL | 1998年 / 93卷 / 07期

关键词：

D O I：

10.1016/S0092-8674(00)81456-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A single molecule of F-1-ATPase, a portion of ATP synthase, is by itself a rotary motor in which a central gamma subunit rotates against a surrounding cylinder made of alpha(3)beta(3) subunits. Driven by three catalytic beta s, each fueled with ATP, gamma makes discrete 120 degrees steps, occasionally stepping backward. The work done in each step is constant over a broad range of imposed load and is close to the free energy of hydrolysis of one ATP molecule.

引用

页码：1117 / 1124

页数：8

共 37 条

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